PLoS Medicine has an article today entitled "Children Are Not Just Small Adults: The Urgent Need for High-Quality Trial Evidence in Children". According to several investigations, >50% of medications used in pediatrics have not been specifically tested to verify their safety and efficacy in children.
If children are so important to us as a society, then why don't we value their health?
PLoS Medicine also has an original paper in this edition that examines the differences in anti-epileptic drugs in children and adults. This study is meta-analysis, therefore it combines many previous studies to examine subtle trends that can be revealed by adding together the patients from other studies. They show that kids are more likely to experience the placebo effect than adults. Although the specifics of what they showed is not incredibly important, the study is particularly interesting because it is an example that kids don't respond to medication in the same way as adults, i.e. it is difficult to directly apply adult studies to children.