tag:blogger.com,1999:blog-3509053156280655479.post6596637970992576795..comments2023-06-14T08:24:18.553-04:00Comments on The Feminist Underground: Gender differences in medical care and mortalityhabladorahttp://www.blogger.com/profile/01730183259272125337noreply@blogger.comBlogger8125tag:blogger.com,1999:blog-3509053156280655479.post-89086439541981973882008-08-25T23:24:00.000-04:002008-08-25T23:24:00.000-04:00You are right, it is a gross simplification. NO i...You are right, it is a gross simplification. <BR/><BR/>NO inhibits the cytochrome P450 enzymes and is how physiology regulates them. Low NO disinhibits them, which is why the P450 enzymes are pretty uncoupled, that is they produce a lot of superoxide, which pulls down the NO level and disinhibits them so they "do their thing" somewhat faster. <BR/><BR/>NO causes expression of the phase II daedalus2uhttps://www.blogger.com/profile/10416564922288784455noreply@blogger.comtag:blogger.com,1999:blog-3509053156280655479.post-54267108649543339162008-08-25T21:08:00.000-04:002008-08-25T21:08:00.000-04:00Actually, current data suggest that it's not nitri...Actually, current data suggest that it's not nitric oxide (at least not directly), but rather the CYP 450 system that's involved. The toxins are metabolized in a 2-step process: first oxidized by the cytochrome system, then conjugated by aldehyde oxidase. Elimination requires both steps, but estrogen upregulates only the first. The problem is that the oxidized crud builds up and causes all Another Anonymous Posterhttps://www.blogger.com/profile/10805120757173334654noreply@blogger.comtag:blogger.com,1999:blog-3509053156280655479.post-45964394128380125252008-08-25T21:02:00.000-04:002008-08-25T21:02:00.000-04:00Daed--that is a grossly over-simplified view of th...Daed--that is a grossly over-simplified view of the mechanisms of disease. As a basic player in cell signaling NO may play some role, it is not going to be the only/primary instigator.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-3509053156280655479.post-55412877524117750482008-08-25T18:43:00.000-04:002008-08-25T18:43:00.000-04:00I think it is nitric oxide. Estrogen activates th...I think it is nitric oxide. Estrogen activates the estrogen receptor which causes activation of nitric oxide synthase and makes NO. People are pretty sure that that contributes to the reduced incidence of heart disease in pre-menopausal women. That is probably the mechanism for a lot of the reduced incidence of many diseases in pre-menopausal women. The loss of that NO is what causes daedalus2uhttps://www.blogger.com/profile/10416564922288784455noreply@blogger.comtag:blogger.com,1999:blog-3509053156280655479.post-5148962687314456412008-08-25T17:51:00.000-04:002008-08-25T17:51:00.000-04:00The ad is incredibly sexist, too. You can imagine ...The ad is incredibly sexist, too. You can imagine a room full of male ad executives scheming on how to sell to women.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-3509053156280655479.post-7062821343406230492008-08-25T10:53:00.000-04:002008-08-25T10:53:00.000-04:00The post was great, but I also wanted to comment o...The post was great, but I also wanted to comment on the ad: WOW, that's kind of crazy. I always think that gendered ads for gender neutral items are so weird. It's as if you can see the wheels turning in their heads "how can we make this a product geared towards men/women?!" Often, they fail miserably, IMO.sallyhttps://www.blogger.com/profile/01054413520223145494noreply@blogger.comtag:blogger.com,1999:blog-3509053156280655479.post-64546477121764797112008-08-24T21:40:00.000-04:002008-08-24T21:40:00.000-04:00Awesome post, Loup.If anyone has an historical ben...Awesome post, Loup.<BR/><BR/>If anyone has an historical bent, check out <A HREF="http://lane.stanford.edu/tobacco" REL="nofollow">this link</A> to Stanford University's medical library site. If you click on "targeting women" on the left, they've got a summary of the tobacco companies' efforts to market to women from the 1920s on, as well as images of old ads (like the one that Loup included).<Another Anonymous Posterhttps://www.blogger.com/profile/10805120757173334654noreply@blogger.comtag:blogger.com,1999:blog-3509053156280655479.post-68601054482130360152008-08-24T21:25:00.000-04:002008-08-24T21:25:00.000-04:00Wow, interesting post. Why do you think that wome...Wow, interesting post. Why do you think that women are more likely to be misdiagnosed? The same is true for heart disease, right? Why are women being assumed to have less serious diseases? And what is going on in the South East to shorten women's lives?habladorahttps://www.blogger.com/profile/01730183259272125337noreply@blogger.com